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Call for Paper - May 2015 Edition
IJCA solicits original research papers for the May 2015 Edition. Last date of manuscript submission is April 20, 2015. Read More

Study of miRNA Let-7 Involvement in Breast Cancer through the Light of Graph Theory and Canalizing Function

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IJCA Proceedings on National Conference cum Workshop on Bioinformatics and Computational Biology
© 2014 by IJCA Journal
NCWBCB - Number 3
Year of Publication: 2014
Authors:
Antara Sengupta
Camellia Ray
Pabitra Pal Choudhury

Antara Sengupta, Camellia Ray and Pabitra Pal Choudhury. Article: Study of miRNA Let-7 Involvement in Breast Cancer through the Light of Graph Theory and Canalizing Function. IJCA Proceedings on National Conference cum Workshop on Bioinformatics and Computational Biology NCWBCB(3):26-29, May 2014. Full text available. BibTeX

@article{key:article,
	author = {Antara Sengupta and Camellia Ray and Pabitra Pal Choudhury},
	title = {Article: Study of miRNA Let-7 Involvement in Breast Cancer through the Light of Graph Theory and Canalizing Function},
	journal = {IJCA Proceedings on National Conference cum Workshop on Bioinformatics and Computational Biology},
	year = {2014},
	volume = {NCWBCB},
	number = {3},
	pages = {26-29},
	month = {May},
	note = {Full text available}
}

Abstract

miRNAs are small, non-coding RNAs and of 21-25 nucleotide in size. They negatively regulate protein-coding mRNAs at the post-transcriptional level. miRNAs play very important roles in various biological processes like cell growth, differentiation, and development. Abnormal expressions of miRNAs can lead various diseases including cancer and therefore miRNAs are considered as strong diagnostic and therapeutic candidates for the treatment of human diseases. The let-7 "lethal-7" is a microRNA and has active participation in Breast cancer. Not only that but also let-7 affects self-renewal ability of cancer cells. So it may be novel idea to make cancer therapy by targeting let-7 in breast cancer patients. In this paper we have tried to study the Gene Regulatory Network(GRN) of Let-7 in Breast Cancer through the light of Graph theory and Canalizing function.

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