An In-Silico Approach to Confront Monoamine Oxidase by Synthetic and Herbal Antidepressant Drug
Anita Margret. A, Nargis Begum. T, Prakash. P and Jesubalan. S. Article: An In-Silico Approach to Confront Monoamine Oxidase by Synthetic and Herbal Antidepressant Drug. IJCA Proceedings on National Conference cum Workshop on Bioinformatics and Computational Biology NCWBCB(3):1-4, May 2014. Full text available. BibTeX
@article{key:article,
author = {Anita Margret. A and Nargis Begum. T and Prakash. P and Jesubalan. S},
title = {Article: An In-Silico Approach to Confront Monoamine Oxidase by Synthetic and Herbal Antidepressant Drug},
journal = {IJCA Proceedings on National Conference cum Workshop on Bioinformatics and Computational Biology},
year = {2014},
volume = {NCWBCB},
number = {3},
pages = {1-4},
month = {May},
note = {Full text available}
}
Abstract
Monoamine oxidase (MAO) is an enzyme that metabolizes monoamines, and are also vital to the inactivation of monoaminergic neurotransmitters, such as serotonin, norepinephrine, dopamine for which they display different specificities. Lower level of such neurotransmitters leads to depression which is considered to be a menace in current scenario and there is need for a treatment. Hence it is necessary to confront Monoamine oxidase (MAO). Antidepressant drugs are formulated to handle a sensitive issue called depression where Venlafaxin a synthetic drug is a highly configured drug for depression . This is referred with Lithium carbonate a chemical which generally has the capacity to tackle depression. The study alternatively compares the compounds essential as anti depressant in Clitoria ternatea which is said to be a brain tonic and Hypericum perforatum whose capsules are standardized as antidepressant drugs. The phytocompounds along with Venlafaxine and lithium carbonate is contested to evaluate their efficiency to combat the protein Monoamine oxidase thereby conflicting depression.
References
- Shanahan, M. J. , Hofer, S. M. 2005. Social context in gene-environment interactions: Retrospect and prospect, J . Gerontol . B. Psychol. Sci. Soc. Sci. 60, 65–76.
- Raine, A. 2008. From genes to brain to antisocial behavior, Curr. Dir. Psychol. Sci. 17, 323–328.
- Shih, J. , Chen, K. 1999. MAO-A and -B gene knock-out mice exhibit distinctly different behavior, Neurobiology. 235–246.
- Caspi ,A. , McClay, J. , Moffitt, T. E. , Mill, J. , Martin, J. , Craig, W. ,Taylor, A. , Poulton . R. 2002. Role of genotype in the cycle of violence in maltreated children, Science, 297, 851–854.
- Caspi, A. , Mof?tt, T. E. 2006. Gene-environment interactions in psychiatry: joining forces with neuroscience, Nat Rev Neurosci, 7, 583–590.
- Frazzetto, G. , Di Lorenzo ,G. , Carola ,V. , Proietti, L. , Sokolowska, E. , Siracusano, A. , Gross, C. , Troisi . 2007. A Early trauma and increased risk for physical aggression during adulthood: The Moderating role of MAOA genotype, PLoS One 2, e486.
- Muth, E. A. , Haskins, J. T. , Moyer, J. A. , Husbands ,G. E. , Nielsen, S. T. , Sigg, E. B. 1986 Antidepressant biochemical profile of the novel bicyclic compound, Wy-45,030, an ethyl cyclohexanol derivative, BiochemPharmacol, 4, 4493-4497.
- Sethiya, N. K. , Nahata,A. , Mishra, S. H. , Dixit,V. K. ,2009. An update on Shankhpushpi, a cognition- boosting ayurvedic medicine, J Chin Integr Med, 7, 1001-1022.
- Gomez ,S. M. , Kalamani, A,. 2003. Butter-fly Pea (Clitoriaternatea): A nutritive multipurpose forage legume for the tropics- an overview, Pakistan Journal of Nutrition, 6, 374-379.
- Kumar, V. , Mukherjee , K. , Kumar, S. , Mal ,M. , Mukherjee, P. K. ,2008. Validation of HPTLC method for the analysis of taraxerol in Clitoriaternatea, Phytochem Anal, 19,, 244-250.
- Anita Margret, Aishwarya, Violet Dhayabaran, 2013. Steering up brain drug targeting:anin-silico approach to combat the drug efflux permeability glycoprotein (p-gp) with antidepressant drug Venlafaxin and phytocompounds of Clitoriaternatea , International Journal of Universal Pharmacy and Bio Sciences 2(4): 186-197.